Nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) are the two closest precursors to nicotinamide adenine dinucleotide (NAD+), a vital coenzyme in cellular energy metabolism, present in every one of our cells. NAD+ is indispensable for mitochondrial function, facilitating the production of adenosine triphosphate (ATP), the primary energy currency of cells. Given that NAD+ cannot directly cross cell membranes due to its size, its precursors, NMN and NR, are essential for intracellular NAD+ biosynthesis. Cyanide has the exact opposite effect on cells. It blocks NAD+ production, killing you almost instantaneously. So, the opposite of instant death should be good, right?

Mitochondrial ATP Production and NAD+

Mitochondria generate ATP through oxidative phosphorylation, a process heavily reliant on NAD+. NAD+ functions as an electron carrier, accepting electrons during glycolysis and the citric acid cycle to form NADH. NADH then donates these electrons to the electron transport chain, culminating in ATP synthesis. Deficient intracellular NAD+ concentration impairs mitochondrial function, reduces ATP production, and compromises cellular energy status and homeostasis, damaging overall health.

NMN and NR as NAD+ Precursors

NMN and NR are the first two molecular NAD+ precursors. NR enters cells through specific transporters and is phosphorylated by nicotinamide riboside kinases to form NMN, which is subsequently converted to NAD+ by NMN adenylyltransferase enzymes, researchers think. There are still many questions about the specific mechanisms and pathways involved. NMN enters cells directly through other transporters and is converted to NAD+ inside the cell.

Supplementation with NMN and NR has been shown to significantly elevate intracellular NAD+ levels, enhancing mitochondrial function, ATP production, and cellular homeostasis. I like these two molecules so much because they are working on one of the most basic fundamental components of life, energy production. If we don’t have enough energy, it is impossible to function optimally, making it impossible to achieve optimal health.

Chronic Sympathetic Hyperactivity and Energy Deficiency

Chronic sympathetic hyperactivity, characterized by prolonged increased activation of the sympathetic autonomic nervous system, elevates metabolic demands on the brain and body. Sympathetic hyperactivity increases heart rate, blood pressure, and overall energy expenditure, necessitating augmented ATP production to sustain heightened neurophysiologic activity. In the United States, the prevalence of chronic disease associated with sympathetic hyperactivity is totally insane. The fact that about 80% of the US population is currently overweight, obese, or morbidly obese, guarantees this portion of the population is living with chronic sympathetic autonomic hyperactivity. Sympathetic autonomic nervous system hyperactivity is the most common underlying cause of chronic disease, which further dysregulates the autonomic nervous system, forming a health-destroying feedback loop.

Consequences of NAD+ Depletion

Diminished NAD+ levels lead to mitochondrial dysfunction, resulting in decreased ATP production. This energy deficit impairs neuronal function, leading to cognitive decline, mood disorders, and other mental health impairments. Physically, reduced ATP availability causes muscle weakness, fatigue, organ dysfunction, and a lot more bad stuff. Additionally, Inadequate NAD+ impairs DNA repair mechanisms and other important epigenetic mechanisms of action, which disrupts cellular signaling pathways, accelerates aging, and increases susceptibility to neurodegenerative and age-related disease.

Supplementation with NMN and NR

Supplementing with NMN and NR replenishes NAD+ levels, enhances mitochondrial function, and amplifies ATP production. Studies have demonstrated that NMN and NR supplementation improve mitochondrial function and ATP production throughout the brain and body, giving cells the energy they require to do the stuff they need to maintain and improve health and homeostasis.

The FDA is Trying to Ban NMN

The FDA is currently in the process of trying to ban NMN from the marketplace because it’s a natural molecule that improves people’s health, and cannot be patented. Natural molecules cannot be patented. The FDA could not care less if this is all to the direct detriment of public health, which it is, because health has nothing to do with their goals, money is all that matters to the people in charge, period. This is how we get to a place in time where as our medical technology and understanding are better than ever in human history, the health of the country is worse than ever in history, by far, and is rapidly getting even worse.

This is what these psychopathic criminals do. If the “Public Health” system and Pharma, but I repeat myself, find a super safe and effective treatment, but it’s a natural substance they can financially cripple the American public with by selling it to them in pill form, injection, or whatever, they immediately ban it, outright lie and say it’s dangerous, while at the same time they start pouring hundreds of millions of research dollars into changing the molecular structure enough to where they can patent it.

However, this molecular restructuring is what causes all the serious negative side-effects to appear when none were present before. This is exactly what they did with Ozempic, by the way, which is based on a natural peptide called semaglutide. In proper dosage, semaglutide has zero serious adverse side-effects. Ozempic has a ton of serious adverse side-effects that are known, and I promise you, the worst of the side effects, which will take time to materialize, are being actively hidden from the general public. Just like they did with the health destroying “treatment” for Covid they coerced or forced upon most of the population in 2020.

Following 2020, the average lifespan of the population started to drop for the first time in a century, young people with no prior health problems started having heart attacks, including pro-athletes, and 5 years after the fact, the life expectancy is still declining. And no, the virus itself did not drop the life expectancy at all. Zero percent. The average age of death was over the average lifespan, which does not drop the average, simple math.

And does anyone in power care? Fuck no, are you kidding me? They are some of the most profitable “treatments” Pharma has ever created, which is why they are now the standard of care. this is precisely why they tell people to take these things for life, get boosters, etc., while they explicitly tell people to not change anything else about their lifestyle, eating habits, nothing. You know, the reasons people are overweight in the first place, which was also the number one indicator of potential serious problems if you got covid.

If you never treat the cause of a problem and only treat a symptom, nothing will ever get solved and the drug becomes “necessary” for life, which makes a tiny percentage of people a massive amount of money, while public health continues to get worse. But don’t worry, there is a pill they can sell you for that!

Conclusion

NMN and NR are natural, safe, effective NAD+ precursors that enhance mitochondrial function and ATP production. In conditions of chronic sympathetic hyperactivity where energy demands are increased, maintaining adequate NAD+ concentration is crucial to avoid severe consequences. Supplementation with NMN and NR is an excellent way to support cellular energy metabolism, mitigating the adverse effects associated with NAD+ depletion, which could be just about any mental or physical impairment depending on the individual.

No matter what pathology or impairment you may be dealing with, or what medical intervention you may be receiving in attempt to resolve said pathology, if your mitochondria don’t have the electron energy they require to produce the energy our cells require, nothing will ever be resolved, and you will be unhealthy for life. As is the current state of reality for about 80% of the country, about 270 million people.